Evidence for Ku70/Ku80 association with full-length RAG1
نویسندگان
چکیده
منابع مشابه
Evidence for Ku70/Ku80 association with full-length RAG1
Antigen receptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination. This process proceeds through two distinct phases: a cleavage phase in which the RAG1 and RAG2 proteins introduce DNA double-strand breaks at antigen receptor gene segments, and a joining phase in which the resulting DNA breaks are processed and repaired via the non-homologous end-joini...
متن کاملVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.
The N-terminus of full-length RAG1, though dispensable for RAG1/2 cleavage activity, is required for efficient V(D)J recombination. This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-length RAG1 functions as a single subunit or a multi-subunit E3 ligase in vivo is unclear. We show the multi-subunit cullin RING E3 ligase complex VprBP/DDB1/Cul4A/Roc1 associates wit...
متن کاملPredicting full-length transcripts.
genes in genomic DNA. Curr. Opin. Struct. Biol. 8, 346–354 10 Stormo, G.D. (2000) Gene-finding approaches for eukaryotes. Genome Res. 10, 394–397 11 Reese, M.G. et al. (2000) Genome annotation assessment in Drosophila melanogaster. Genome Res. 10, 483–501 12 Gelfand, M.S. et al. (1996) Gene recognition via spliced sequence alignment. Proc. Natl. Acad. Sci. U. S. A. 93, 9061–9066 13 Florea, L. e...
متن کاملChallenging for Expression Bovine Rotavirus (RF Strain) Full-Length VP7 Protein in Prokaryotic System
Background and Aims: Rotavirus enteritis is an acute viral infectious disease among infants. VP7 protein has a key role in attachment and entry virus into the target cell. The VP7 protein is involved in inducing the production of neutralizing antibodies that protect infants against reinfection of the virus. The aim of this study was to heterologous expression of the VP7 gene of bovine rotavirus...
متن کاملEvidence for a Complex Mosaic Genome Pattern in a Full-length Hepatitis C Virus Sequence
The genome of the hepatitis C virus (HCV) exhibits a high genetic variability. This remarkable heterogeneity is mainly attributed to the gradual accumulation of mutational changes, whereas the contribution of recombination events to the evolution of HCV remains controversial so far. While performing phylogenetic analyses including a large number of sequences deposited in the GenBank, we encount...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2008
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkn049